Therapeutic rationale for low dose doxepin in insomnia patients
نویسندگان
چکیده
منابع مشابه
Low-dose doxepin for the treatment of insomnia: emerging data.
BACKGROUND Doxepin is a tricyclic compound that has been used extensively for the treatment of depressive and anxiety disorders for approximately thirty years. It was noted early to have sedative effects and assist with the improvement of disrupted sleep patterns, but in higher antidepressant doses it was also noted to have significant anticholinergic and antinoradrenergic properties. These pro...
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Doxepin Hydrochloride is an antidepressant which though widely used abroad, is relatively new on the Indian scene. Chemically, Doxepin, is N, N-Dimethyldibenz (b, e) oxepinii(6H) propylamine hydrochloride (Krakowsi, 1968). Doxepin, being a tricyclic compound, has its basic action similar to other compounds of the group (Groton, 1967). It is tertiary amine like Amitriptyline and Imipramine which...
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INTRODUCTION Pruritus is one of the frequent discomforting complications in patients with end-stage renal disease. We prospectively evaluated the effectiveness of doxepin, an H1-receptor antagonist of histamine, in patients with pruritus resistant to conventional treatment. MATERIALS AND METHODS A randomized controlled trial with a crossover design was performed on 24 patients in whom other e...
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INTRODUCTION Although a variety of pharmacologic and non-pharmacologic treatments are effective for insomnia in the general population, insomnia in Parkinson's disease differs in important ways and may need different treatments. No studies have conclusively demonstrated effective insomnia treatments in Parkinson's disease. METHODS We conducted a three-arm six-week randomized pilot study asses...
متن کاملEfficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders
Anxiety disorders are frequently comorbid with insomnia, and sleep disturbance in patients with anxiety disorders is the most common complaint. Antidepressants can affect sleep quality; however, their effect in patients with comorbid insomnia and anxiety disorders is unclear. The aim of the present study was to comprehensively evaluate the dose, treatment duration, treatment efficacy and safety...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Tropical Disease
سال: 2013
ISSN: 2222-1808
DOI: 10.1016/s2222-1808(13)60080-8